Occasionally you may come across issues with SIP inspection on an ASA or Firepower, leading to problems with SIP/RTP voip audio. As a troubleshooting step, it’s often helpful to disable SIP inspection for testing.
Please read this note from Cisco on disabling SIP inspection to verify you everything in order before doing so:
You would typically disable SIP only if the inspection is causing problems in the network. However, if you disable SIP, you must ensure that your access control policies allow the SIP traffic (UDP/TCP 5060) and any dynamically allocated ports, and that you do not need NAT support for SIP connections. Adjust the access control and NAT policies accordingly through the standard pages, not through FlexConfig.